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NCAA Basketball: Top 10 Round of 64 upsets to bet in 2022 NCAA Tournament

Feb 2, 2022; Houston, Texas, USA; Houston Cougars players celebrate during the final seconds against the Tulane Green Wave during the second half at Fertitta Center. Mandatory Credit: Erik Williams-USA TODAY Sports
Feb 2, 2022; Houston, Texas, USA; Houston Cougars players celebrate during the final seconds against the Tulane Green Wave during the second half at Fertitta Center. Mandatory Credit: Erik Williams-USA TODAY Sports
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NCAA Basketball NCAA Tournament Oral Roberts Golden Eagles guard Max Abmas Ohio State Buckeyes Joshua Bickel-USA TODAY Sports
NCAA Basketball NCAA Tournament Oral Roberts Golden Eagles guard Max Abmas Ohio State Buckeyes Joshua Bickel-USA TODAY Sports

When it comes to the NCAA Tournament, many casual fans would say that the best part of the whole event is the upsets that occur in the very first round. It happens all the time, as at least one top-four seed bows out in shocking fashion to a small NCAA Basketball school.

It was absolutely crazy a year ago, there were numerous upsets in the Round of 64. 14 seed  Abilene Christian defeated 3-seeded Texas, while 13 seed Ohio took out 4 seed Virginia. 13 seed North Texas beating 4 seed Purdue also was notable but nothing prepared fans for No. 15 seed Oral Roberts not only beating No. 2 Ohio State but also beating No. 7 Florida in the Round of 32 two days later.

Will there be the same kind of madness in the first few days? Possibly. There are lots of talented mid-major programs that are led by either a bunch of seniors or former power conference athletes that can match up with some of the higher seeds. And either due to injuries or inconsistent play, some of these top teams are vulnerable to a tough early game and potentially even an upset.

There are odds for all of the games, including from our very own WynnBet. And if you notice from some of the game predictions, we could have some fairly close games come down to the wire. So if you’re a betting man, which of the games are most likely to end up as complete upset winners?

Here’s a look at my top 10 bets to make in the first round when it comes to picking an upset or two.