Arkansas head coach John Calipari hosts a former longtime rival at Bud Walton Arena, where his Hogs have yet to lose this season, while Louisville rides in at a perfect 7-0, reaching No. 6 in the latest AP poll before the scheduled ACC/SEC Challenge.
Pat Kelsey’s bunch enters Wednesday’s non-conference meeting against Arkansas with one of the best offenses in the nation, spearheaded by likely future lottery pick Mikel Brown Jr. Through seven games, Louisville earned two quality wins over Kentucky and Cincinnati, but have yet to play a true road game.
Freshmen Darius Acuff and Meleek Thomas run the show for Arkansas, who has lost to Michigan State and Duke, during its hellacious non-conference slate that includes future games against Texas Tech and Houston. The Hogs will search for a signature win against the Cardinals, which Calipari played frequently while coaching at Kentucky, where he won 13 of 16 games against the in-state rival.
Louisville vs. Arkansas: When and Where
Date: Wednesday, December 3, 2025, 7 p.m. ET
Location: Bud Walton Arena in Fayetteville, Ark
Louisville vs. Arkansas: Where to Watch or Stream
Watch: ESPN
Streaming: YouTube TV
Louisville vs. Arkansas: Betting Odds
Spread: Louisville Cardinals -3.5, Arkansas Razorbacks +3.5
Moneyline: Louisville Cardinals -155, Arkansas Razorbacks +135
Total: 165.5
Louisville vs. Arkansas: Series History
All time series: Tied at 4-4
Last meeting: Arkansas 80, Louisville 54 (November 21, 2022)
Projected Starting Lineups
Louisville
Ryan Conwell (20.1 ppg, 5.4 rpg)
Mikel Brown Jr. (17.0 ppg, 6.0 apg)
Isaac McKneely (12.3 ppg, 3.6 rpg)
Sananda Fru (9.9 ppg, 5.9 rpg)
J’Vonne Hadley (9.3 ppg, 5.7 rpg)
Arkansas
Darius Acuff (17.4 ppg, 4.4 apg)
Trevon Brazile (12.7 ppg, 7.7 rpg)
DJ Wagner (8.4 ppg, 3.9 apg)
Karter Knox (8.5 ppg, 5.8 rpg)
Nick Pringle (6.1 ppg, 5.3 rpg)
The turnover battle may swing Wednesday’s top 25 matchup, Arkansas protects it well while Louisville turns opponents over with the best of them. Calipari’s crew must find ways to steal extra possessions despite below average offensive rebounding numbers. Louisville launches three-pointers at the nation’s third-highest rate, so running the Cards off the line will be key for the Hogs.
Arkansas aims to pick up its first ranked win of the year, while Louisville seeks to stay perfect. Can Calipari continue his dominance against Louisville or will Kelsey and company hand Arkansas its third loss of the season?