A major Atlantic Coast Conference showdown takes center stage Monday night as the Louisville Cardinals visit the Duke Blue Devils at Cameron Indoor Stadium. This marks the second meeting between two of the ACC’s top teams this season. Duke took the first matchup earlier this month, and both teams enter playing high-level basketball. Louisville is 14–5 on the season, while Duke sits at 18–1 and remains one of the most consistent teams in the country.
Louisville enters the game riding back-to-back wins, including a home victory over Virginia Tech. The Cardinals have won six of their last ten games overall, with their most recent loss coming at home against Virginia. They also dropped a road game at Stanford earlier this month. Offensively, Louisville has been one of the more explosive teams in the nation, averaging 87.8 points per game and ranking inside the top 10 nationally in three-pointers made at 12 per game. Guard Ryan Conwell has led the way, averaging 19.5 points per game and pacing a balanced attack that features five players scoring in double figures.
Duke comes in off a dominant performance against Wake Forest, scoring 90 points in what became their seventh straight win. On the season, the Blue Devils are averaging just under 86 points per game and continue to overwhelm opponents with depth and efficiency. Their lone loss came on December 20 against Texas Tech. After this matchup, Duke heads to Virginia Tech on Saturday before turning its attention to rivalry games against North Carolina, beginning February 7, with the regular-season finale set for March 7 in Durham.
Louisville vs. Duke: When and Where
- Date: Monday, January 26, 2026
- Time: 7:00 p.m. ET
- Location: Cameron Indoor Stadium, Durham, North Carolina
Louisville vs. Duke: How to Watch or Stream
- TV: ESPN
- Streaming: FuboTV
Louisville vs. Duke: Betting Odds
- Spread: Duke -7.5 | Louisville +7.5
- Moneyline: Duke -325 | Louisville +250
- Total: 157.5
Louisville vs. Duke: Series History
- All-time series: Duke leads 15–9
- Last meeting: Duke defeated Louisville 84–73 on January 6, 2026
Projected Starting Lineups
Louisville Cardinals
- #3 Ryan Conwell – 19.5 PPG
- #00 Mikel Brown Jr. – 16.9 PPG
- #10 Isaac McKneely – 11.8 PPG
- #13 Sananda Fru – 10.9 PPG
- #1 J’Vonne Hadley – 10.8 PPG
Duke Blue Devils
- #12 Cameron Boozer – 23.7 PPG
- #3 Isaiah Evans – 14.4 PPG
- #21 Patrick Ngongba II – 11.0 PPG
- #1 Caleb Foster – 8.9 PPG
- #7 Dame Sarr – 6.1 PPG
ACC Showdown Outlook
This game has all the makings of a statement night in the ACC. Louisville, under Pat Kelsey, looks like a legitimate threat to make a deep NCAA Tournament run, pairing elite scoring with balance across the lineup. Duke continues to reload at an elite level, and after a Final Four appearance, the Blue Devils once again have the talent and depth to contend nationally. Expect a high-level, high-energy battle as two conference heavyweights close out the month with one of the ACC’s most anticipated games.