We have officially reached the end of 2025. Happy New Year’s Eve, college basketball fans. Conference play is ramping up across the country, and the calendar flipping to 2026 brings a different level of urgency to these games.
Best Bets for Wednesday
We closed Tuesday in perfect fashion, going 5-0 on the day, pushing our season record to 135-115-4. A strong finish to the year, and now one more slate to wrap things up.
As always, be sure to track and follow all of our picks throughout the season via BetStamp. Here are our best bets for Wednesday night.
Wake Forest Demon Deacons at North Carolina State Wolf Pack
An early ACC matchup with two teams sitting at 9-4. NC State opens conference play at home, and the crowd should provide a boost. Wake Forest is good enough to hang around, however, keeping this one competitive for most of the night. NC State pulls away late, but the Demon Deacons do enough to cover.
Betting Pick: Wake Forest Demon Deacons +10 over North Carolina State Wolf Pack
Final Score Prediction: North Carolina State 80, Wake Forest 72
Virginia Cavaliers at Virginia Tech Hokies
Virginia enters ranked 21st in the country at 11-1, but this is a difficult road spot against a hot in-state rival. Virginia Tech is 11-2 and riding a five-game winning streak. With both teams playing well, home court becomes the deciding factor in a tight ACC battle.
Betting Pick: Virginia Tech Hokies +4.5 over Virginia Cavaliers
Final Score Prediction: Virginia Tech 75, Virginia 74
St. Bonaventure Bonnies at VCU Rams
St. Bonaventure comes in at 11-2, but road conference games in the A-10 are rarely easy. VCU has won three straight and is coming off a dominant win over Rider. The Rams find a way to win at home, but the Bonnies keep it within the number.
Betting Pick: St. Bonaventure Bonnies +11.5 over VCU Rams
Final Score Prediction: VCU 80, St. Bonaventure 75
UConn Huskies at Xavier Musketeers
UConn hits the road under Dan Hurley to face a Xavier team that sits at 9-4 and is coming off a much-needed road win at Georgetown. The Huskies are the better team and should control the game, but Xavier’s home floor helps keep things closer than expected.
Betting Pick: Xavier Musketeers +12.5 over UConn Huskies
Final Score Prediction: UConn 72, Xavier 68
DePaul Blue Demons at Villanova Wildcats
This one sets up as a mismatch. DePaul already has five losses, and Villanova has looked every bit like a Big East contender at 10-2. The Wildcats take control early and never look back in a lopsided home win.
Betting Pick: Villanova Wildcats -13.5 over DePaul Blue Demons
Final Score Prediction: Villanova 90, DePaul 60
Good luck with all of your Wednesday night college basketball action. Whether you are following or fading, be sure to check in with our picks all season long through BetStamp as we head into 2026.